"My Friend's Little Sister Has It In for Me" is romantic comedy anime series based on the light novel series of the same name (also known in Japan as "ImoUza!") written by Ghost Mikawa and illustrated by Tomari. The light novel is licensed in North America by J-Novel Club. A manga adaptation by Hira Hiraoka began serialization online in December 2019.
Kazuomi Koga ("Rent-a-Girlfriend") directs at studio BLADE, with Toko Machida ("With You and the Rain") on series composition, Katsuyuki Sato ("Hokkaido Gals Are Super Adorable!") on character designs and Tsugumi Tanaka, Kaho Sawada, Kanade Sakuma and Hanae Nakamura on music.
The opening theme song is "Uza Kawaiikute Nani ga Warui!" ("What's Wrong with Being Annoyingly Cute!") performed by Karubi Akami, while Kohana Lam performs the ending theme titled "Hoshi no Kodou" ("The Pulse of the Stars"). The voice cast includes Sayumi Suzushiro, Haruki Ishiya, Tomori Kusunoki, Soma Saito and Kana Hanazawa.
"My Friend's Little Sister Has It In for Me" premiered on October 4, 2025 and also streams on Crunchyroll.
Find out more about the anime series after the jump.